Place it at the end of an opening setup, just after the line that sets up the joke, then follow it with Woody Woodpecker Laugh to stretch the reaction. For a messier sequence, put Fart Echo immediately before it so the two gags land as one escalating bit.
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This is a short, roughly one-and-a-half-second voice clip built around a single drawn-out utterance of the word 'boobs' in a deliberately crude, teenage delivery. It lands as instantly immature and giggly, the kind of joke that works because it is so blunt and juvenile. The line comes from the animated television series Beavis and Butt-Head.