The line comes from the 1978 college comedy Animal House, where Dean Vernon Wormer, played by John Vernon, warns Flounder that Fat, drunk, and stupid is no way to go through life, son. The quote became one of the film's most repeated lines, printed on posters and quoted in college culture for decades. Online it survived as a short reaction sound because the wording is self contained, the delivery is memorable, and it fits any moment of self inflicted foolishness without needing the rest of the scene.