Tom and Jerry began in 1940 as MGM theatrical cartoon shorts created by William Hanna and Joseph Barbera, with Hanna himself providing many of Tom's famous vocal outbursts. Decades of television reruns kept those screams familiar to new audiences, and short clips later spread online as reaction audio. Numbered variants like this one come from different chase and injury gags, which explains the slightly different pitch and length. It now works as a classic scream meme that needs no setup to understand.