Place it near the end of a short reaction sequence, after an Awkward Moment beat sets up the embarrassment, then follow it with an Anime Ahh to keep the reaction going into the next scene.
關於此聲音
This short clip captures Nene in a tearful, rising cry that stretches into a long, wailing 'awooou', delivered in a high, expressive anime voice over about two and a half seconds. It feels melodramatic and funny at once, like a cartoon breakdown pushed just past serious into silly, which makes the sadness land as comedy rather than real distress.