The clip comes from Family Guy, from Season 4, Episode 9 of the animated sitcom created by Seth MacFarlane that premiered on Fox in 1999, with MacFarlane voicing Peter Griffin, the show's clumsy central character. The show's cutaway gags and exaggerated physical comedy helped short moments like this vomiting scene travel far beyond the episode, first through clip compilations and soundboards, then across YouTube and TikTok edits. It remains popular because Peter's reaction is instantly recognizable, even without the animation, turning a two second sound into shorthand for extreme disgust.
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Peter Griffin vomiting sound effect from Family Guy, the gross out gag used for disgust, bad food and cringe moments in meme edits and reaction videos.
This is Peter Griffin retching loudly in the exaggerated cartoon style Family Guy is known for, with gagging, spluttering and a drawn out heave that sounds deliberately over the top. The audio is short and unmistakable, built around the physical comedy of a character reacting to something revolting. It lands instantly as a joke because the vomiting is so theatrical rather than realistic. Viewers hear disgust, embarrassment and slapstick failure all at once, which makes the clip perfect for punctuating a gross moment on screen without needing any dialogue or explanation to understand it.