The line comes from the 1989 comedy National Lampoon's Christmas Vacation, starring Chevy Chase as Clark Griswold. Randy Quaid's Cousin Eddie arrives uninvited for Christmas and is later seen emptying his RV toilet in the street, greeting Clark with the explanation that it was full. The scene became one of the film's most quoted moments and a staple of holiday replays, merchandise and memes. Online, the short audio is reused far beyond Christmas as a shorthand reaction for septic tanks, portable toilets and any container that can hold no more.
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The 'shitter's full' line from National Lampoon's Christmas Vacation, delivered by Cousin Eddie while emptying his RV tank, used for plumbing fail jokes.
This is Cousin Eddie's cheerfully blunt announcement from National Lampoon's Christmas Vacation, delivered while he stands outside in a bathrobe emptying his RV's chemical toilet into a storm drain. He says the line casually, as if reporting the weather, which is what makes the disgusting detail so funny. The clip captures that proud, oblivious tone in just a few seconds, with no embarrassment at all. Played on its own it instantly signals a toilet, tank or drain that has reached capacity, turning an ordinary plumbing problem into a crude Christmas movie punchline.