The line comes from Filthy Frank, the abrasive character played by George Miller on YouTube in the early 2010s, whose exaggerated disgust became a template for reaction editing. As short clips moved to soundboards and meme pages, this is cancer was detached from its original video and reused on its own, in the same rotation as the emotional damage meme and other verdict style reactions. It survives because the wording is instantly clear without context, letting one line stand in for a whole negative review.