Place it at the peak of a fail, after Sudden Suspense has built the tension and just before the aftermath lands. Follow it with Sad Violin as the closing note, letting the joke settle before the next clip begins.
Über diesen Sound
The clip is a short 2.5-second voice recording of a man crying out 'Oh, the humanity!' in a distraught, rising voice. It feels horrified and dramatically over the top, turning shock into instant mock despair. It comes from Herbert Morrison's live radio report of the Hindenburg airship disaster in 1937, where his emotional reaction became one of the most quoted lines in broadcast history.