Place it at the point where a setup loses its thread, then follow it with the shocked meme sound for the reaction shot, and hold that second beat before cutting back to normal dialogue or gameplay.
Über diesen Sound
This is a 3.6-second clip titled 'Que de' followed by a string of plus signs, leaving the phrase deliberately incomplete. It feels puzzling and abrupt, like a thought cut short before it explains itself, giving listeners a brief confused pause that works as a reaction beat.