The laugh comes from Dinner for Schmucks, the 2010 comedy in which Zach Galifianakis plays Therman Murch, a socially awkward taxidermist whose uncontrollable giggle becomes one of his defining traits. In the film, Therman's wheezing laugh punctuates his deadpan stories and unsettling confidence, making the character instantly memorable. Clips of the laugh later circulated on YouTube and soundboards, where editors stripped it from dialogue so it could be reused on its own. It remains popular because the sound instantly signals awkward, helpless laughter without needing any context from the movie.