The clip comes from Mario Party, Mario Party 2 and Mario Party 3 for the Nintendo 64, released between 1998 and 2000, where Luigi reacts this way after misfortune on the board or in a mini-game. As Mario Party clips spread through forums, videos and soundboards, this particular reaction became shorthand for Luigi's bad luck, much like the ROBLOX oof became shorthand for a character getting hurt. Its brevity and instant recognisability keep it in rotation for edits, streams and memes about losing at the worst possible moment.