C quoi une couisse circulates online as a short French reaction sound, shared on soundboards and in chat clips rather than tied to a confirmed film, show or creator. The humour comes from the spelling and the literal question, since couisse twists the everyday word cuisse, meaning thigh, into something that sounds made up. French-speaking users pass it around as a quick voice reply, while others use it simply for its confused tone, even without understanding every word. Its brevity and odd phrasing have kept it in rotation as a reusable meme reaction.