The line comes from Re Zero Starting Life in Another World, the anime series that premiered in 2016. Rem is a blue haired maid and one of its most popular characters, but in the story her name and memories are consumed, leaving almost everyone unable to remember her. Other characters asking who she is turned into a long running fan joke, and the short question spread across forums, Discord servers and edited clips as shorthand for a beloved character being erased or overlooked, which is why the phrase is still quoted and posted today.
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Short anime voice clip of the line who's Rem from Re Zero, used as a meme reaction when someone forgets a character or pretends not to know them.
This is a short voice clip of the question who's Rem, asked in a confused and flat tone. The line lasts just over two seconds, with the emphasis falling on Rem's name as if the speaker has genuinely never heard it before. Its humor comes from that blank delivery, which makes it perfect for moments of fake forgetfulness. Viewers who know the character feel the sting immediately, while everyone else hears a simple, dismissive way to pretend someone important does not exist.