The line comes from Red Dwarf, the British sci-fi sitcom that debuted in 1988. In the first episode, the ship's computer Holly calmly informs crew member Dave Lister that a radiation leak killed everyone aboard, delivering the immortal line 'Everybody's dead, Dave.' The deadpan delivery made it one of the show's most quoted moments. Decades later the clip resurfaced as a reaction sound online, dropped over a total wipeout in gaming videos or an empty lobby, where its dry delivery turns a disaster reaction into a joke.