This sound comes from the U.S. version of The Office, spoken by Michael Scott, played by Steve Carell. The scene became a major reaction meme through reposts, GIFs, and short-form edits because the delivery is instantly recognizable and exaggerated in a funny way. It remains popular for moments of rejection, panic, or comic despair, often filling the same role as a quick nope in edits where a simple negative reaction is not dramatic enough.