Place it at the end of a failed play or boast, after the setup has finished, then follow it with an awkward moment sting to keep the gag going. For a bigger reaction, lead in with a WTF boom before the gag, or swap in a SpongeBob boowomp when you want a cartoon fail instead.
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This short clip pairs a fart sound effect with D.Va from Overwatch, lasting just under five seconds. It feels deliberately disgusting and awkward, built to undercut a serious moment with childish shock humour. It is a fan-made meme, not an official Overwatch voice line, and it works because the familiar character makes the crude gag land instantly.