The phrase you can't be serious has long been an everyday expression of disbelief, and as a short audio clip it fits naturally into the reaction sound format popular on meme pages and short-form video. Creators reuse it because the wording is instantly understood without explanation, and the tone does the comic work on its own. It is commonly paired with fails, plot twists, surprising announcements and exaggerated stories, where a single line of scepticism can turn an ordinary moment into a joke. Its brevity also makes it easy to loop, remix and drop into edits.