Use it as the closing beat of a failed-plan edit, placed directly after the Mission Failed sting, and let the Drama sting follow only when the scene needs one more beat before the cut to the next moment.
About this sound
This is a 1.2-second Japanese voice line in which Leorio says 'shikata nai', a phrase meaning that nothing more can be done. It carries a dry, resigned humour, the sound of someone giving up an argument rather than winning it. The line comes from the 2011 Hunter x Hunter anime, spoken after Leorio refuses to take his words back.