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The line comes from Grand Theft Auto San Andreas, released in 2004, where protagonist Carl Johnson, known as CJ, says it early in the story on returning to Grove Street. The clip stayed a fond memory for players for years before resurfacing in 2019 as a major meme template. Editors began placing the audio over footage of themselves or fictional characters walking toward a familiar problem, often with the game's opening recreated in real places. Its lasting appeal is the instant recognition among gaming audiences and the perfect summary of reluctant repetition.
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CJ saying ah shit here we go again from GTA San Andreas, the voice line used as a meme sound effect for starting something troublesome all over again.
This is CJ from Grand Theft Auto San Andreas delivering his resigned opening line, ah shit here we go again, in a flat, tired voice that already knows trouble is coming. The delivery is calm rather than angry, with a slow sigh built into the words and a brief pause that makes the dread feel inevitable. That weary tone is why it lands so well as a reaction. Viewers instantly understand the loop of bad luck restarting, and the line turns a frustrating repeat into something funny and familiar before anything else happens.
