Sneakers O'Toole is a minor name gag associated with Family Guy, while Alphus is a robot character from The Desolate Hope, and this clip mashes those references into a short sung meme. Shared on soundboards as a brief, out of context joke, it spread through meme edits where the randomness is the point rather than any plot connection. Listeners rarely need the original context to get it, because the sung name alone sounds funny, which is why the clip keeps circulating as a quick reaction and interruption sound.