Place it as the reaction cut after a No No Wait Wait build-up, when the repeated bit has run its course, then cut straight to Oh My God Wow for the group's response. Keep it as the single reaction in the sequence, so the exchange stays clear and the next line carries the payoff.
About this sound
This is a short German voice clip, about two seconds long, in which a man says 'Ach Mensch, hör auf' in a tired, fed-up tone. It lands as a playful, exasperated shut-down, the kind of line you use when someone is teasing you, repeating themselves, or pushing a joke too far, and it works because the delivery sounds genuinely worn out rather than angry.