The phrase big ups to my boy plays on slang for giving respect and credit, here directed at Spider-Man as if he were a close friend. That mismatch is why the clip circulates as a short meme sound rather than a straight movie quote. It is shared in gaming clips, edits and reaction posts where someone performs a heroic save or appears in costume, and the familiar superhero name makes the joke clear even to viewers hearing it for the first time without context.