Place it as the punchline after a confused setup, then follow it with a long brain fart for a bigger reaction or a fart with reverb when the joke needs more room. For a deadpan contrast, put a bruh before it so the blank stare sets up the gag.
About this sound
This 1.75-second clip pairs a brain-fart gag with a crude poop sound effect, the kind of low, cartoonish noise used to puncture a serious moment. It feels silly, gross and instantly awkward, landing as a cheap laugh rather than a clever joke. The sudden, bodily humour makes it work best as a quick reaction when someone says something nonsensical or embarrassing.