Place it near the start of an edit, just after the setup, so the entrance lands before the joke. Follow it with Directed by Robert B. Weide for a sudden anticlimax, or with Yeah Reaction when a character agrees with the swagger. Keep it as the entrance cue, not the punchline.
About this sound
This is a short, about six-second clip of the smooth saxophone hook from Careless Whisper, played cleanly with no vocals. It feels suave, wistful and slightly over-dramatic, like a slow-motion entrance or a knowing glance. The hook comes from George Michael's 1984 song, and the meme version isolates that instantly recognisable opening riff.