In Colombian Spanish, cómo así is a familiar way of asking how something can be so, while ñerito is an affectionate diminutive form of ñero, a slang word for a friend or mate. Put together, the phrase works as a light-hearted challenge to something surprising, which is why it has travelled as a meme reaction in short-form videos, edits and chat clips rather than as a line from a known film or show. Creators reuse it to voice the audience's own disbelief, especially when a claim, twist or fail needs no further commentary.