Place this clip at the punchline beat, right after the setup lands. Follow it with the Vine Boom Sound Effect for a bigger reaction, or precede it with the SpongeBob Fail Sound Effect when the mistake needs building up first.
About this sound
This clip is a very short fart sound effect, a single brief burst lasting under a second. It feels deliberately childish and rude, instantly making a moment feel embarrassing and silly. The humour comes from how blunt it is, undercutting anything serious with one immature hit that needs no setup or explanation to land.