This sound is known from The Binding of Isaac: Rebirth, the 2014 remake of the indie roguelike shooter. Short, exaggerated effects from Isaac spread widely because players clipped bizarre deaths, item interactions and room clears for forums, streams and meme edits. This particular splattery cue stuck around online thanks to its instantly readable gross-out tone. Even outside Isaac content, creators keep using it when a scene needs a fast, nasty comedic hit that feels more absurd than realistic.