The line comes from Austin Powers: International Man of Mystery (1997), where Mike Myers plays the bumbling British spy Austin Powers with an exaggerated lisp. His mangled 'exsqueeze me' became one of the character's signature catchphrases alongside his other one-liners. As clips circulated on early soundboards, YouTube compilations and later TikTok, creators adopted it as a shorthand for a cheeky interruption. It endures because the mispronunciation is instantly recognizable and funnier than a plain excuse me.