The line comes from the Assassin's Creed games, where Ezio Auditore, the Renaissance assassin introduced in Assassin's Creed II, lives by the Brotherhood's creed that nothing is true and everything is permitted. It sums up the order's belief that people should question dogma and judge for themselves. Fans have reused Ezio's delivery in edits, tributes and memes for years because it sounds like a timeless philosophy rather than a throwaway game quote, making it a shorthand for secrets, freedom and rebellion.