The line comes from Fable, the 2004 action role-playing game developed by Lionhead Studios, where the Guildmaster guides the hero from the Heroes' Guild. During training and early quests he repeats the warning whenever health drops, asking about potions or food that restore health. Because players heard it so often, the quote spread through forums, videos and soundboards as shorthand for obvious gaming advice. It remains popular in remixes of Fable Anniversary and in broader low-health memes long after release.