Place it in the middle of a painting or tutorial edit, after a setup clip and before a reaction sound, so the edit moves from focus to a reveal. Follow it with DJ Airhorn for a bigger reveal, or with Windows XP Error Music when the artwork goes wrong.
About this sound
A nearly 18-second Family Guy clip built around Bob Ross, with his soft painting-show voice turned up for comic effect. It feels warmly familiar at first, then suddenly absurd as the gentle tone gets much bigger than expected, which makes it funny rather than relaxing. It comes from Family Guy's take on the painter.