Put it in the edit just as the question appears on screen, so it works as the direct answer. Follow it with Oh My God Wow as the next reaction to the answer, or use Ceeday Huh instead when you want the next beat to question it.
About this sound
This is a short, just-over-three-seconds clip of a woman's voice saying she is from the United States, delivered in a single plain line. The feeling is straightforward and slightly awkward, as if she is answering a simple question with more confidence than the moment needs. That blunt directness is what makes it work as a quick, funny reaction.