Place it near the end of a Horimiya edit, just after the teasing exchange, then follow it with Anime Ahh for a playful reaction and Awkward Moment if the joke needs a beat to settle before the next scene.
About this sound
This is a short dubbed voice line from the first episode of Horimiya, lasting about 1.9 seconds, in which the speaker delivers the title line. It feels cheeky and reassuring at once, turning a teasing remark about flat-chested girls into a lighthearted compliment. The clip comes from the English dub of Horimiya episode one.