Fullmetal Alchemist: Brotherhood premiered in Japan in 2009 as the second anime adaptation of Hiromu Arakawa's manga. It follows brothers Edward and Alphonse Elric, who search for the Philosopher's Stone after a failed alchemy attempt changes their bodies. The series became one of the most widely praised anime of its era, and clips linked to it spread through fan edits, forums and soundboards. Fans still use this sound today to reference alchemy, sacrifice and determination without needing a long clip from an episode.