Put it at the end of a compliment setup, right after the setup line, so the payoff lands last. Follow it with Bruh for a deadpan cut, or with Emotional Damage when the praise backfires, and let the reaction clip close the edit.
About this sound
This nine-second clip pairs a long, strained groan with a voice saying you're beautiful, turning a simple compliment into something deliberately awkward and overdone. The groan drags out the praise until it feels both flattering and ridiculous, which makes it land as a joke rather than a straight compliment. It works best when the listener already expects something sincere and gets this instead.