Halo Reach, released by Bungie in 2010, included Infection as a tense multiplayer mode in which a small group of infected players hunted survivors and turned them on contact, echoing the Flood from the wider Halo story. The cue became shorthand for that turning point, first in gameplay recordings and later in short-form gaming edits where a single sound could explain a whole reversal. It endures because the idea is instantly readable even without Halo knowledge: one player changes sides, and the danger suddenly grows.