House, also known as House M.D., premiered on Fox in 2004 and starred Hugh Laurie as Dr Gregory House, a medical genius whose chronic leg pain led to a well known Vicodin addiction. That dependency was a running part of the character across eight seasons, so short lines about needing drugs became shorthand for House online. The clip circulated on soundboards and in meme edits as a reaction for cravings and overdoses of anything, from coffee to gaming, long after the series ended in 2012.