Place it at the end of a confusing scene as the final reaction, then follow it with Law and Order Dun Dun for a sudden reveal, or let SpongeBob Sad Song take over when the moment turns to defeat instead of answers.
About this sound
This is a short voice clip, lasting about seven seconds, in which a speaker turns to god with a single desperate question, stretching out the word why until it sounds almost like a plea. It feels exasperated and theatrical, funny because the frustration is so over the top, and it works best as an exaggerated reaction to something that makes no sense at all.