Place it as the punchline after the innocent line that sets up the double meaning, then follow it with a reaction sound for the group's response. Pairing it with the Bruh sound keeps the focus on the group's response, while the Oh My God Meme sound works when the reply needs a bigger reaction from the group.
About this sound
This clip is a single spoken line built around the pun in its title, lasting just under three seconds. A voice delivers 'Innuendo, in my endo' as a quick, deliberate wordplay joke, with the second half landing as the punchline. It feels cheeky and deliberately awkward, the kind of line that gets a groan and a laugh at the same time when it catches someone mid-sentence.