This sound is commonly identified by players as an Isaac hurt noise from The Binding of Isaac series, which began in 2011 and became a staple of indie roguelike culture. Short character damage sounds from the game spread through gameplay clips, stream highlights and meme edits because they instantly communicate failure or bad luck. It still gets used in gaming content for quick, readable reactions, especially when a creator wants a softer pain cue than a dramatic scream like the Roblox oof.