Place it at the end of a setup, after the obvious point has landed, then follow it with a short agreement sound for the reply. A laugh works well after that agreement, giving the exchange a clear finish without adding another line.
About this sound
This is a short voice clip of J-Roc delivering his catchphrase, 'Know what I'm sayin'?', in a relaxed, knowing drawl over about three seconds. It feels laid-back and conspiratorial, like a nudge to someone who already agrees with you. The line comes from Trailer Park Boys, where it became his signature catchphrase.