Use it as the punchline after a clip of someone overreacting, using Oh My God Wow to set up the drama before the dismissal, then follow it with Damn to underline that the conversation is finished and you are moving on.
About this sound
This one-second clip is a single French voice delivering the blunt phrase 'J'en ai rien à foutre' in a dismissive, fed-up tone. It lands as pure dismissal, the sound of someone shutting down a conversation they have no interest in continuing. It feels rude, funny and oddly freeing, like finally saying out loud that you simply do not care.