Place it as the payoff at the end of a short question-and-answer edit, after the silly question has fully landed. Follow it with Bruh for a deadpan reaction, or pair it before Emotional Damage when the insult needs a bigger comic fallout.
About this sound
This 1.75-second clip is Dross delivering the Spanish insult 'Me cago en tu hermana' in a blunt, dismissive voice, straight from a segment where he answers stupid questions. It feels rude, shocking and deliberately over the top, like a verbal slap meant to shut down a ridiculous question rather than start a real argument.