Place it at the end of a short setup showing the foolish question, then follow it with Emotional Damage for a bigger fallout or a Bruh as the closing reply, keeping the insult as the turning point of the edit.
About this sound
Dross says 'me cago en tu madre' in a short, hard-edged shout that runs for less than two seconds as he answers a daft question. It feels rude, heated and oddly funny, the kind of outburst that cuts a silly remark dead. The line is from Dross's online videos, where he throws it back at daft questions.