Place it as the final beat after a clip of someone making an obvious claim, then follow it with the Bruh sound for a second reaction, or use the Emotional Damage sound first to build up the overreaction before this line closes the joke.
About this sound
This is a very short Spanish voice clip, lasting just over a second, in which a man states flatly, in Spanish, that marijuana is a drug. The deadpan delivery makes it feel blunt, awkward and unexpectedly funny, like a serious statement dropped into a silly conversation. It comes from Argentine journalist Eduardo Feinmann, whose line became a meme.