The phrase of all people has long been used in everyday speech to express surprise that a particular person, rather than anyone else, is involved in something. As a standalone soundboard clip, it works because that meaning needs no explanation, so creators have reused it across reaction videos, meme edits and short-form clips whenever an unexpected character or friend enters a scene. Its appeal is its versatility: the same few words can sound amused, annoyed or genuinely shocked depending on the context around them, which keeps it useful for new jokes rather than tying it to one moment.