Desuwa is the signature catchphrase of Salome Hyakumantenbara, a virtual YouTuber with Nijisanji who built her online persona around an elegant, ojou-sama style of speech. Fans clipped her playful use of the phrase and paired it with moments of surprise, turning oh no desuwa into a reaction sound shared across short-form videos and streams. Its appeal comes from the contrast between the polite, theatrical delivery and the sudden panic, which makes it instantly recognisable to VTuber audiences and easy to reuse in new memes.