Place it near the end of a fail edit, after the mistake is clear, then follow it with the Womp Womp Fail Sound to underline the defeat, or open with the SpongeBob Disappointed Sound before it for a slower build to the same ending.
About this sound
This nearly ten-second clip is Kazuhira Miller asking, “Why are we still here? Just to suffer?” in a tired, pained voice that sounds worn down and sincere. It feels bleak and melodramatic, which makes ordinary disappointment seem much larger and funnier by contrast. The line comes from Metal Gear Solid V: The Phantom Pain, released in 2015.