Place it as the payoff after a short build-up, then follow it with Emotional Damage to keep the joke going, or open with Oh My God Bro Oh Hell Nah before it for a longer reaction sequence.
About this sound
This 4.3-second clip delivers the Spanish exclamation 'Oh no, es un hijo de puta' in one blunt, exasperated burst, with the emphasis landing hard on the insult. It feels shocked, disgusted and darkly funny, like a reaction to news that is too awful to soften. The line comes from Stranger Things.