The line comes from South Park, the animated comedy created by Trey Parker and Matt Stone that premiered on Comedy Central in 1997. In the show's early seasons Kenny died in almost every episode, and Stan and Kyle reacted with the same horrified routine each time. Parker voices Stan and Stone voices Kyle, making the exchange a running gag viewers expected weekly. As South Park clips spread on early video and meme sites, the shout escaped the show and became a universal shorthand for a sudden, ridiculous character death.
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The famous South Park line where Stan and Kyle shout after Kenny dies, used as a reaction sound for shocking deaths and fail moments in videos
This is the classic South Park catchphrase shouted in panic whenever Kenny McCormick meets his sudden, absurd death. Stan Marsh delivers the shocked 'Oh my God, they killed Kenny' and Kyle Broflovski follows with the furious reply, creating a perfect two-part reaction. The delivery is high pitched, frantic and instantly recognisable even without the picture. In edits the clip acts as a punchline for a character wipeout, a gaming death or an unexpected fail, because the over the top horror contrasts so sharply with the silly cartoon situation that follows in most memes.
